C16 Ceramide

CAS No. 24696-26-2

C16 Ceramide( —— )

Catalog No. M34959 CAS No. 24696-26-2

C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 37 Get Quote
10MG 56 Get Quote
25MG 109 Get Quote
50MG 165 Get Quote
100MG 241 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    C16 Ceramide
  • Note
    Research use only, not for human use.
  • Brief Description
    C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.
  • Description
    C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding.
  • In Vitro
    C16-Ceramide interacts with p53 within its core domain. p53 forms complex with natural C16-Ceramide in the cell.C16-Ceramide (2.5-50 μM; 0-48 h) strongly decreased HCT116 cell viability in a time- and concentration-dependent manner.C16-Ceramide (12 μM; 48 h) induces apoptosis through Btf (Bcl-2-associated transcription factor) in HCT116 cells.C16-ceramide (12 μM; 0-6 h) and Btf expression up-regulate p53 and BAX expression. C16-ceramide down-regulates Mdm2 expression via Btf.Cell Viability Assay Cell Line:HCT116 cells Concentration:2.5, 5, 10, 12, 20, 50 μM Incubation Time:0-48 h Result:Strongly decreased cell viability in a time- and concentration-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:12 μM Incubation Time:1, 3 and 6 h Result:Increased PARP cleavage, decreased pro-caspase 3. Decreased the levels of stratifin and stathmin, increased the expression of prohibitin and Btf. RNAi-mediated Btf depletion also partially inhibited BAX expression after the treatment. Significantly decreased luciferase activity and Mdm2 protein expression levels.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    p53
  • Recptor
    p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    24696-26-2
  • Formula Weight
    537.9
  • Molecular Formula
    C34H67NO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 20 mg/mL (37.18 mM; warming and heat to 60°C)DMF : 20 mg/mL (37.18 mM; Ultrasonic (<60°C))
  • SMILES
    CCCCCCCCCCCCCCCC(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fekry B, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018 Oct 8;9(1):4149.?
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