
C16 Ceramide
CAS No. 24696-26-2
C16 Ceramide( —— )
Catalog No. M34959 CAS No. 24696-26-2
C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 37 | Get Quote |
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10MG | 56 | Get Quote |
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25MG | 109 | Get Quote |
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50MG | 165 | Get Quote |
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100MG | 241 | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameC16 Ceramide
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NoteResearch use only, not for human use.
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Brief DescriptionC16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.
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DescriptionC16-Ceramide is a natural small molecule activating p53 through the direct and selective binding.
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In VitroC16-Ceramide interacts with p53 within its core domain. p53 forms complex with natural C16-Ceramide in the cell.C16-Ceramide (2.5-50 μM; 0-48 h) strongly decreased HCT116 cell viability in a time- and concentration-dependent manner.C16-Ceramide (12 μM; 48 h) induces apoptosis through Btf (Bcl-2-associated transcription factor) in HCT116 cells.C16-ceramide (12 μM; 0-6 h) and Btf expression up-regulate p53 and BAX expression. C16-ceramide down-regulates Mdm2 expression via Btf.Cell Viability Assay Cell Line:HCT116 cells Concentration:2.5, 5, 10, 12, 20, 50 μM Incubation Time:0-48 h Result:Strongly decreased cell viability in a time- and concentration-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:12 μM Incubation Time:1, 3 and 6 h Result:Increased PARP cleavage, decreased pro-caspase 3. Decreased the levels of stratifin and stathmin, increased the expression of prohibitin and Btf. RNAi-mediated Btf depletion also partially inhibited BAX expression after the treatment. Significantly decreased luciferase activity and Mdm2 protein expression levels.
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In Vivo——
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Synonyms——
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PathwayApoptosis
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Targetp53
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Recptorp53
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Research Area——
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Indication——
Chemical Information
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CAS Number24696-26-2
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Formula Weight537.9
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Molecular FormulaC34H67NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?Ethanol : 20 mg/mL (37.18 mM; warming and heat to 60°C)DMF : 20 mg/mL (37.18 mM; Ultrasonic (<60°C))
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SMILESCCCCCCCCCCCCCCCC(=O)NC(CO)C(O)C=CCCCCCCCCCCCCC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fekry B, et al. C16-ceramide is a natural regulatory ligand of p53 in cellular stress response. Nat Commun. 2018 Oct 8;9(1):4149.?
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